Liqui-Mass Technology as a Novel Tool to Produce Sustained Release Liqui-Tablet Made from Liqui-Pellets

The Liqui-Mass technology (also known as Liqui-Pellet technology) has shown promising results in terms of enhancing the drug release rate water insoluble drugs a simplistic approach. However, there is no current study on sustained-release formulation using technology. In this study, an attempt was made to produce Liqui-Tablet for first time matrix-based non-volatile co-solvent used investigation included Tween 80, 20 and Kolliphor EL. production propranolol hydrochloride successful, data from saturation solubility test dissolution did not show much difference among mentioned co-solvent. best took 24 h reach at around 100%. There seemed be synergistic retarding effect when Eudragit RS PO were together. increase concentration increased retardant effect. Kinetic analysis suggests that followed Higuchi model. flowability pre-compressed pellets had issues its size distribution narrow. generally robust most formulations passed friability test. revealed can employed sustain release.